Inhibition of mitochondrial fragmentation during sake brewing causes high malate production in sake yeast期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Inhibition of mitochondrial fragmentation during sake brewing causes high malate production in sake yeast

Authors:	Kitagaki Hiroshi Kato Taku Isogai Atsuko Mikami Shigeaki Shimoi Hitoshi

Affiliation:	^aNational Research Institute of Brewing, 3-7-1 Kagamiyama, Higashi-hiroshima City, Hiroshima 739-0046, Japan;^bDepartment of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima 739-8530, Japan

Abstract:	We previously demonstrated the presence and fragmentation of mitochondria during alcohol fermentation. Here, we show that Fis1p induces mitochondrial fragmentation, and inhibition of mitochondrial fragmentation causes higher malate production during sake brewing. These findings indicate that mitochondrial morphology affects the metabolism of constituents, providing a breeding strategy for high-malate-producing yeasts.

Keywords:	malate alcohol fermentation sake yeast mitochondria Fis1p
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