Effect of plant sterols,fatty acids and lecithin on cholesterol absorption in vivo in the rat |
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Authors: | Daniel Hollander MD Donna Morgan |
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Affiliation: | (1) University of California, 92717 Irvine, CA;(2) the Veterans Administration Medical Center, 90822 Long Beach, CA;(3) Department of Medicine, University of California, Irvine, Med Sci I, Room C360, 92717 Irvine, CA;(4) Present address: Division of Immunology, Wayne State University, Detroit, MI |
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Abstract: | The inhibitory effect of plant sterols, fatty acids and lecithin on cholesterol intestnal absorption was studied in the unanesthetized
rat using a single pass perfusion technique. Bile was excluded from the perfused intestine. Cholesterol absorption did not
change following the additions of cholestanol, cholestanone, lanosterol, stigmasterol and β-sitosterol. A 3-fold increase
in the molarity of cholestanol and β-sitosterol or the separate additions of the saturated short and medium chain fatty acids,
butyric and octanoic, also did not change cholesterol absorption. The unsaturated long chain fatty acids, oleic, linoleic,
linolenic and arachidonic, inhibited cholesterol absorption. Lecithin additions at concentrations of 0.1–1.5 mM caused a progressive,
dose-related inhibition of cholesterol absorption. The inhibitory effect of these agents on cholesterol absorption is likely
to have been caused by changes in cholesterol solubility in the micelle and shifts in the partition coefficient of cholesterol
away from the cell membrane to the micelle. |
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