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Quest for the Crypto-phosphoproteome |
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| Authors: | Seungmin Ahn Hoyoung Jung Prof. Dr. Jung-Min Kee |
| Affiliation: | 1. Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919 Korea;2. Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919 Korea These authors contributed equally to this work. |
| Abstract: | Protein phosphorylation is one of the most studied post-translational modifications (PTMs). Despite the remarkable advances in phosphoproteomics, a chemically less-stable subset of the phosphosites, which we call the crypto-phosphoproteome, has remained underexplored due to technological challenges. In this Viewpoint, we briefly summarize the current understanding of these elusive protein phosphorylations and identify the missing pieces for future studies. |
| Keywords: | binding domains kinases phosphatases phosphoproteome protein phosphorylation |