A novel bilayer drug-loaded wound dressing of PVDF and PHB/Chitosan nanofibers applicable for post-surgical ulcers |
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| Authors: | Fatemeh Amini Saeed Karbasi Seyedeh Nooshin Banitaba |
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| Affiliation: | 1. Department of textile engineering, Isfahan University of Technology, Isfahan, Iran;2. Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran |
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| Abstract: | A novel bilayer nanofibrous wound dressing, with enhanced mechanical properties is successfully fabricated. This membrane, consisted of polyvinylidenefluoride (PVDF) nanofibers for providing tensile strength and polyhydroxybutyrate/chitosan (PHB/CTS) nanofibers loaded with gentamicin with ability of controlled drug delivery, is a great choice for post-surgical ulcers. Mechanical properties showed dramatically improvement of tensile strength by addition of PVDF layer. Gentamycin release represented both an immediate and a sustained release of about 24?h and 1 week, respectively and release increment with increase of CTS ratio. Results also revealed that drug release in structures follow first order kinetic and Fickian release mechanism. |
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| Keywords: | Drug-loaded nanofibers nanofiber post-surgical ulcer wound dressing |
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