Preparation of hydrogel nanoparticles by atom transfer radical polymerization of N-isopropylacrylamide in aqueous media using PEG macro-initiator |
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Authors: | Keon Hyeong Kim Won Ho Jo |
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Affiliation: | a Hyperstructured Organic Materials Research Center, School of Materials Science and Engineering, Seoul National University, Seoul 151-742, South Korea b Polymer Hybrids Center, Korea Institute of Science and Technology, Seoul, South Korea |
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Abstract: | PEG-b-PNIPAM block copolymers are synthesized by the atom transfer radical polymerization of NIPAM using PEG macro-initiator. When the polymerization temperature is 25 °C, the block copolymer is soluble in water, whereas the block copolymer is phase-separated to form micelles during polymerization as the polymerization temperature is raised to 50 °C, the temperature above the LCST of PEG-b-PNIPAM. To prepare stable hydrogel nanoparticles in water at room temperature, a small amount of N,N′-ethylenebisacrylamide is added as a cross-linker to the reaction system, where the size of nanoparticles is controlled by the composition of mixed solvent. |
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Keywords: | Atom transfer radical polymerization N-isopropylacrylamide Nanoparticles |
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