| 双氢青蒿素对前列腺癌裸鼠种植瘤CHOP表达的影响 |
| |
| 引用本文： | 李剑,王红,范京川,王婧,罗子国.双氢青蒿素对前列腺癌裸鼠种植瘤CHOP表达的影响[J].四川激光,2011(6):93-94. |
| |
| 作者姓名： | 李剑 王红 范京川 王婧 罗子国 |
| |
| 作者单位： | 重庆医科大学生命科学院,重庆400016 |
| |
| 摘 要： | 目的：研究双氢青蒿素对前列腺癌PC-3细胞裸鼠种植瘤CHOP表达的情况,并探讨其作用途径及机制。方法：采用人前列腺癌PC-3细胞建立裸鼠种植瘤模型,20只模型鼠随机分为对照组、溶剂组、实验1组及实验2组,经13d干预后,免疫组织化学法检测CHOP的表达水平;透射电子显微镜观察DHA对PC-3细胞种植瘤超微结构的影响。结...
|
| 关 键 词： | 双氢青蒿素 前列腺癌 凋亡 内质网 |
Effects of Dihydroartemisinin on expression of CHOP in transplanted prostate cancer |
| |
| LI Jian,WANG Hong,FAN Jing-chuang,WANG Jing,LUO Zi-guo.Effects of Dihydroartemisinin on expression of CHOP in transplanted prostate cancer[J].Laser Journal,2011(6):93-94. |
| |
| Authors: | LI Jian WANG Hong FAN Jing-chuang WANG Jing LUO Zi-guo |
| |
| Affiliation: | (Institute of Life Sciences in Chongqing Medical University,Chongqing 400016,China) |
| |
| Abstract: | Objective： To investigate the effects of Dihydroartemisinin（DHA）on expression of CHOP and the underlying molecular mechanism in transplanted prostate cancer in nude mice.Methods： Twenty nude mice were randomly divided into four groups with five mice in each group： control group,solvent group,1 st experimental group and 2nd experimental group.PC-3 cells were transplanted into every mouse.The expression of CHOP was tested by immunohistochemical medthod after drug administration.Effects of DHA on ultrastructure of transplanted prostate cancer by transmission electron microscope（TEM）.Results： The expression of Endoplasmic Reticulum stress-associated gene CHOP was increased in experimental group（p0.05）.Conclusion： The mechanism of DHA induced PC-3 cell apoptosis might be related with ERS. |
| |
| Keywords: | dihydroartemisinin prostate cancer apoptosis endoplasmic reticulum |
| 本文献已被 维普 等数据库收录！ |
|
