RSM法优化微波场下壳聚糖降解

采用响应曲面法分析了壳聚糖质量分数、pH值以及微波辐射时间对壳聚糖相对分子质量的影响,并建立了相应的预测模型.在微波功率为528 W时,壳聚糖质量分数、pH值及微波辐射时间对壳聚糖的相对分子质量有显著的影响.相对分子质量为1.00×10^4的低聚壳聚糖,模型优化所得的较优工艺参数：质量分数为4.55%,pH值为7.7,辐射时间为54.8 min,对应的相对分子质量试验值为9.75×10^3.通过验证证明,所得到的壳聚糖降解工艺参数是可行的,并得到一个能较好预测试验结果的模型方程.

OPTIMIZATION OF DEGRADABILITY OF CHITOSAN UNDER MICROWAVE IRRADIATION USING RSM

Response surface methodology （RSM） was employed to analyze the effects of mass fraction of chitosan, pH and irradiation time on molecular weight of adhesive intensity. The prediction models were also established. With irradiation power is 528 W, the analysis of variance revealed that mass fraction of chitosan, pH and irradiation time significantly affected response variables. The motivation for intending low-molecular-weight chitosan, the molecular of viscosity average was 1.00×10^4, optimum conditions was as follows： the mass fraction of chitosan, pH, and irradiation time were 4.55 %, 7.7 and 54.8 min respectively. The testing value was 9.75 × 10^3. The results elucidated that these values of optimum conditions were experimentally verified and a model equation that can be used to predict the experiment.