Solubility of niflumic acid and celecoxib in supercritical carbon dioxide |
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| Affiliation: | 1. Department of Chemical Engineering, University of Kashan, Kashan, Iran;2. Department of Chemical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran;1. Department of Chemical Engineering, Faculty of Engineering, University of Kashan, 87317-53153, Kashan, Iran;2. Laboratory of Supercriritcal Fluids and Nanotechnology, University of Kashan, 87317-53153, Kashan, Iran;3. Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, 87317-53153, Kashan, Iran;1. Department of Chemical Engineering, Faculty of Engineering, University of Kashan, 87317-53153, Kashan, Iran;2. Laboratory of Supercriritcal Fluids and Nanotechnology, University of Kashan, 87317-53153, Kashan, Iran;3. Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, 87317-53153, Kashan, Iran;4. South Zagros Oil and Gas Production, National Iranian Oil Company, 7135717991, Shiraz, Iran;1. Department of Chemical Engineering, Faculty of Engineering, University of Kashan, 87317-53153, Kashan, Iran;2. Laboratory of Supercriritcal Fluids and Nanotechnology, University of Kashan, 87317-53153, Kashan, Iran;3. Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, 87317-53153, Kashan, Iran;4. South Zagros Oil and Gas Production, National Iranian Oil Company, 7135717991, Shiraz, Iran;1. Chemical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Mahshahr Campus, Mahshahr, Iran;2. Gas Engineering Department, Petroleum University of Technology, Ahwaz, Iran;3. School of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, China;4. Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Ministry of Education of China, Chongqing University, Chongqing 400044, China |
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| Abstract: | The solubility data of two fluorinated and non-steroidal anti-inflammatory drugs, niflumic acid (CAS No. 4394-00-7) and celecoxib (CAS No. 169590-42-5), in supercritical carbon dioxide were measured with a semi-flow type phase equilibrium apparatus at temperatures ranging from 313.2 K to 353.2 K and pressures up to 31 MPa. At the highest extraction temperature and pressure, the solubilities are 2.09 × 10−5 and 1.52 × 10−5 in mole fraction for niflumic acid and celecoxib, respectively. The saturated solubility data were correlated with the Chrastil model, the Mendez-Santiago–Teja equation, and the Peng–Robinson equation of state. The Chrastil model fitted the experimental data to about within the experimental uncertainty. The correlated results of the Mendez-Santiago–Teja model confirmed the consistency of the solubility data over the entire experimental conditions. Incorporating with two-parameter van der Waals one-fluid mixing rules, the Peng–Robinson equation of state represents satisfactorily the gas–solid equilibrium behavior of niflumic acid and celecoxib in supercritical carbon dioxide. |
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| Keywords: | Niflumic acid Celecoxib Carbon dioxide Solubility |
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