Encapsulation of propolis flavonoids in a water soluble polymer using pressurized carbon dioxide anti-solvent crystallization |
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| Affiliation: | 1. Department of Chemical Engineering, National Chung Hsing University, No. 250, Kuokuang Rd, Taichung 402, Taiwan, ROC;2. Department of Nutrition, China Medical University, No. 91, Hsueh-Shih Rd, Taichung 404, Taiwan, ROC;3. Department of Food Science and Biotechnology, National Chung Hsing University, No. 250, Kuokuang Rd, Taichung 402, Taiwan, ROC;4. Department of Materials Engineering, National Chung Hsing University, No. 250, Kuokuang Rd, Taichung 402, Taiwan, ROC;5. Biotechnology Center, National Chung Hsing University, No. 250, Kuokuang Rd, Taichung 402, Taiwan, ROC;1. Department of Chemical Engineering and Food Technology, Science Faculty, University of Cádiz International Agri-food Campus of Excellence, ceiA3, PO Box 40, Puerto Real, Cádiz 11510, Spain;2. Aix Marseille Université, CNRS, Centrale Marseille, M2P2 UMR 7340, 13451, Marseille, France |
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| Abstract: | This study investigated the pressurized carbon dioxide anti-solvent co-precipitation process (abbr. PAS) on encapsulation of propolis with water soluble polyethylene glycol (PEG). The extent to which recovery of propolis flavonoids, total yield, amount of propolis (i.e. drug content) affects the precipitation was examined using a two-factor central composite schemed experimental design method. Analysis results indicated that the drug content and total yield of the precipitates are conversely related to each other in the PAS process. Additionally, micro-sized amorphous particulates of propolis encapsulated on the surface of PEG were generated, as evidenced by chromatography and X-ray diffraction analyses. Total yield of the PAS co-precipitation process reached 88%, and recovery of propolis flavonoids achieved 97%. Experimental results also indicated that the concentration ratio of propolis to PEG in the feed more significantly affects the drug content than that of the pressure factor. Moreover, nearly spherical and aggregated micro-sized co-precipitated particulates are more soluble in an aqueous solution than those of ethanol extracts. |
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| Keywords: | Propolis Chromatography analysis Drug content Micro-sized co-precipitates Pressurized anti-solvent crystallization |
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