用Excel XP和可见光谱法研讨pH对铜氨配合物定量关系

胆、肾结石形成、骨的钙化和血管粥样硬化等生物体内许多矿化过程的机理非常复杂,有众多组分参与,临床发现生物体矿化异常时氢离子浓度明显偏离正常,尿结石患者的尿液通常pH低。本题研究pH值对金属配合物定量关系及推测它在生物矿化中的作用。选择同时具有酸碱平衡、沉淀平衡、配位平衡的多相化学平衡系统,具有氢氧化铜固体、四氨合铜(Ⅱ)配离子、铜(Ⅱ)离子、氢离子、氢氧根离子、氨的多化学组成为研究对象,通过将高等数学介入化学计算法,从理论上推出pH值对多组分多相化学平衡转换公式,通过计算机Excel XP软件转换函数式与图像和验证可见分光光度法的化学实验手段。结果,有配位剂时,pH显然能影响沉淀与配位转化的多相化学平衡。pH值低时仅有沉淀,且有固定的pH值,足以生成最大配合物的浓度,与配位剂的酸常数pKa相等。推测由于配位剂均是路易斯碱,当尿液偏碱性时有利于形成配合物而不利于形成矿化,生物体液具有不断更新流动的特点,使金属离子更容易以配合物的形式排出体外,则不易发生结石。

The research and discussion of the quantitative relation between pH and copper ( Ⅱ )-ammonia coordination compound by Excel XP software and visible spectroscopy

The biomineralization of gallstone and kidney stone formation, bone calcification and Atherosclerosis their mechanisms are very complicated process, involve different phases and many chemical components. Uric acid stone is referred as the abnormal biomineralization and is easy to formed under the pH low of urine according to clinical data. To study the quantitative relation between pH and Copper( II ) -Ammonia coordination compound by Excel XP software and Visible Spectroscopy as well as in application to metal ionic biomineralization of organism. To select the system of multicomponent and multiphase chemical equilibrium. Through mathematic derivation of stoichimetry,gained the theoretic equation then tested out theories by experiments. Supposing that multiphase coexistence, pH could regulate the conversion from precipitation to coordination equilibrium. The precipitation only exists on pH low and there is the highest concentration of coordination ion on condition that pH equals pKa (coordination agent). To speculate on coordination compound could be propitious to form under the pH high of urine because the coordination agent is Lewis base. The metal-chelated remove since the nephron is a dynamic system.