|
|||||
|
|
Cover Picture: Structure–Activity Relationship Analysis of the Peptide Deformylase Inhibitor 5‐Bromo‐1H‐indole‐3‐acetohydroxamic Acid (ChemMedChem 2/2009) |
|
| Authors: | Sylvain Petit Yann Duroc Dr. Valéry Larue Dr. Carmela Giglione Dr. Carole Léon Dr. Coralie Soulama Dr. Alexis Denis Dr. Frédéric Dardel Prof. Thierry Meinnel Dr. Isabelle Artaud Dr. |
| Affiliation: | 1. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris Descartes, 45 Rue des Saints‐Pères, 75270 Paris Cedex 06 (France), Fax: (+33)?142‐862‐189;2. Institut des Sciences du Végétal, UPR 2355 CNRS, 1 Avenue de la Terrasse, 91198 Gif‐sur‐Yvette (France);3. Laboratoire de Cristallographie et RMN Biologiques, UMR 8015 CNRS, Université Paris Descartes, 4 Rue de l'Observatoire, 75006 Paris (France);4. Société Mutabilis, 102 Avenue Gaston Roussel, 93230 Romainville (France) |
| Abstract: | The cover picture shows a “reverse” indole derivative in complex with Bacillus stearothermophilus peptide deformylase (PDF). This compound was selected from a structure–activity relationship study as a potent inhibitor of bacterial PDFs and shows antibacterial activity toward Bacillus subtilis as well as other pathogens such as Streptococcus pneumoniae and Staphylococcus aureus. For more details, see the Full Paper by I. Artaud et al. on p. 261 ff.  |
| Keywords: | antibiotics indoles inhibitors NMR spectroscopy peptide deformylase |