| 膜技术在万古霉素生产工艺中的应用 |
| |
| 引用本文： | 王琴,宋如,任卓,王荣雪.膜技术在万古霉素生产工艺中的应用[J].河北化工,2007,30(11):50-51. |
| |
| 作者姓名： | 王琴 宋如 任卓 王荣雪 |
| |
| 作者单位： | 1. 华北制药集团金坦公司,河北,石家庄,050011
2. 华北制药华胜股份有限公司,河北,石家庄,052160 |
| |
| 摘 要： | 通过建立连续过滤数学模型VD=VO1n CBO/CE,定采用连续洗滤的操作方法,膜过滤最佳洗涤水量为起始发酵液体积的2.0-2.5倍;通过研究发酵液中固含量对过滤速率的影响,得出发酵液浓缩至原体积的70%-80%,固含量为30%-35%时开始加水洗滤,可以获得最佳操作时间.采用不锈钢膜过滤万古霉素发酵液较板框过滤收率提高15%.
|
| 关 键 词： | 万古霉素 不锈钢微滤膜 收率 |
| 文章编号： | 1003-5095（2007）11-0050-02 |
| 修稿时间： | 2007-07-06 |
Application of Memtrane in Vancomycin Process |
| |
| WANG Qin,SONG Ru,REN Zuo,WANG Rong-xue.Application of Memtrane in Vancomycin Process[J].Hebei Chemical Engineering and Industry,2007,30(11):50-51. |
| |
| Authors: | WANG Qin SONG Ru REN Zuo WANG Rong-xue |
| |
| Affiliation: | 1, NCPC Jintan Co,,Ltd,Shijiazhuang 050011, China;2, NCPC Huasheng Co,,Ltd,Shijiazhuang 052160, China |
| |
| Abstract: | A mathematical module of continuous filtration was established and the optimum volume of washing water was 2.0-2.5 times of the original broth in the continuous filtration. The effect of solids content on filtering rate was studied in this paper. And from the research we made the conclusion that:the optimum operation time could be obtained by starting washing with water whenthe volume of the broth was concentrated to 70%-80% of the original with solids content as 30%-35%. The yield could be increased 15% with the application of mental membrane to vancomycin troth filtration. |
| |
| Keywords: | vancomycin metal microfiltration membrane yield |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
