固相萃取-气相色谱-质谱法测定卷烟主流烟气中4种芳香胺化合物

采用氘代-1-氨基萘作为内标，利用剑桥滤片捕集肯塔基参比卷烟（1R5F、2R4F）烟气，经盐酸超声，二氯甲烷、正己烷萃取，盐酸三甲胺和五氟丙酸酐衍生化，固相萃取仪萃取洗脱纯化后，使用气相色谱-质谱（GC/MS）建立卷烟主流烟气中4种芳香胺化合物的测定方法。4种芳香胺化合物的变异系数均小于5%，回收率在89.8%~106.0%之间，检测限在每支卷烟0.03~0.07 ng之间。该方法具有良好的重复性、准确性，适用于卷烟烟气总粒相物中芳香胺的定量分析。

Analysis of Aromatic Amine in Cigarette Mainstream Smoke by Solid-Phase Extraction and GC/MS

D-1-Naphthylamine as internal standard, four aromatic amines (1-naphthylamine, 2-naphthylamine, 3-aninobiphenyl, 4-aninobiphenyl) in cigarette mainstream smoke were analyzed by GC/MS, through hydrochloric acid ultrasound, methylene dichloride and n-hexane extraction, trimethylamine hydrochloride and pentafluoropropionic anhydride derivation, solid-phase extraction wash and purification process. The RSDs of four aromatic amines are less than 5%, and the recovery are 89.8%-106.0%. The limits of detection of four aromatic amines are 0.03-0.07 ng/cig. The method is accuracy, reproducibility and suits for analysis of four aromatic amines.