微束单细胞照射的研究和发展

了解低剂量辐射效应等辐射生物学基本问题的关键是研究单一粒子与生物体的相互作用。然而 ,由于粒子在能量、径迹上的随机分布 ,这种单一粒子与生物体的相互作用很难在实验室中用常规照射的方法进行。微束的发展 ,特别是单粒子微束通过将精确数量的粒子准确地射入细胞或细胞的特定位置为回答这些问题提供了一个直接 ,有用的手段。该文论述了微束的历史 ,现状和未来发展 ,以及微束在辐射生物学研究中的应用。

Microbeam: Research and Development

The key to answering some fundamental radiation biology questions, such as the hazards of ionizing radiation, is the ability to detect each charged particle as it interacts with a cell. However, due to the stochastic nature of energy deposition and the random position of tracks, these effects cannot be stimulated in the laboratory using conventional broad field exposures. The availability of microbeam, especially the single particle microbeam in the world, whereby individual cells can be irradiated with either a single or an exact number of particles provides a useful tool to address these questions. This report describes the rationale, historical, and nowadays development of microbeam facilities in the world, as well as their biological researches and future development.