Synthesis, structural characterization and microbial activities of mixed ligand copper(II) complexes of 2,2′-bipyridine and acetylacetonate |
| |
| Authors: | OOE Onawumi OA Odunola E Suresh Parimal Paul |
| |
| Affiliation: | aAnalytical Science Division, Central Salt and Marine Chemicals Research Institute (constituents of CSIR, New Delhi), G. B. Marg, Bhavnagar 364002, India;bDepartment of Pure and Applied Chemistry, Ladoke Akintola University of Technology, P.M.B 4000, Ogbomoso Oyo State, Nigeria |
| |
| Abstract: | Two new mixed ligand complexes of copper(II) with acetylacetonate (acac) and 2,2′-bipyridine (bpy) belonging to the class of cytotoxic and antineoplastic compounds known as CASIOPEINAS® have been synthesized and characterized on the basis of analytical and spectroscopic data. Molecular structures of the complexes, Cu(acac)(bpy)Cl]Cu(acac)(bpy)(H2O]Cl.H2O and Cu(acac)(bpy)Br]H2O, were established by single crystal X-ray study. The Cu(II) ion in both the complexes exhibited square pyramidal geometry with acac and bpy in the equatorial plane and halide/water in the axial position. Interestingly, for the complex with chloride anion, two types of complexes with chloride and water at the axial positions were derived from the same reaction and co-crystallized in the asymmetric unit with strong intermolecular interactions. Microbial property of these two complexes as antibacterial and antifungal agents has been investigated and some of the results are comparable to that of the standard drugs such as E. coli, P. aeruginosa, S. aureus, S. pyogenes, A. niger and C. albicans, used in this study. |
| |
| Keywords: | Copper(II) complex Mixed ligand complex Casiopeinas® Crystal structure Microbial activities |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
