| Abstract: | ![]()
70 rats in 7 groups of 10 rats each were studied to determine the effects of an oral administration of 3.3-dibromo-5.5-dichloro-2.2-diphenyl-methane during the period of organogenesis (the 6th-15th day of pregnancy). 5 groups received a dose of 1/1000, 1/500, 1/250, 1/100, and 1/50 of the preparation (LD50) at 1 ml/100/gm of weight. 1 control group received olive oil in a dose of 1 ml/100 gm of weight and the other was given thalidomide at 1/500 LD50. The animals were killed on the 20th day of pregnancy and the fetuses given gross inspections regarding the number of living and dead, the weight of the fetus and of the placenta, the length of the fetus and its tail, and the sex. A statistical analysis using the student t test with a probability of 5% was performed on these data. Autopsies and macroscopic investigations of the liver and kidneys were performed. The development of occipital and interparietal bones, ossification centers in the sternum, and the number of ribs were also assessed. This preparation did not exert any inhibiting influence on fetal development or cause an increase in fetal mortality. |
