Pd[tBuNH(S)NHP(O)(OiPr)2-S]2Cl2 Complex as Air- and Moisture-Stable Catalyst for Palladium Catalyzed Suzuki Cross-Coupling Reaction

A highly efficient Suzuki cross-coupling reaction between phenyl bromide and phenylboronic acid catalyzed by the palladium complex Pd[tBuNH(S)NHP(O)(OiPr)₂-S]₂Cl₂ in acetonitrile, toluene, THF or DMF has been investigated. The bases we have employed for this reaction were Na₂CO₃, K₂CO₃ or Cs₂CO₃. It was established that using DMF and K₂CO₃ at 100 °C shows excellent yields of the product at the catalyst amount of 0.1 mmol. The cross-coupling reactions of iodo- and chloro-benzene with phenylboronic acid were also investigated. The influence of the halide nature was as expected.