| 1-叔丁氧羰基-4-(4,5-二氨基-3-甲基苯基)哌嗪的合成研究 |
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| 引用本文： | 郭力民.1-叔丁氧羰基-4-(4,5-二氨基-3-甲基苯基)哌嗪的合成研究[J].化学与生物工程,2010,27(2):23-25. |
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| 作者姓名： | 郭力民 |
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| 作者单位： | 延安大学化学与化工学院,陕西,延安,716000 |
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| 基金项目： | 陕西省教育厅省属重点科研基金资助项目(06jk155) |
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| 摘 要： | 以碘化亚铜为催化剂、乙二醇为催化剂配体、磷酸钾为碱性介质、异丙醇为溶剂,4-碘-2-甲基-6-硝基苯胺经一步氨基化反应得到了1-叔丁氧羰基-4-(4-氨基-3-甲基-5-硝基苯基)哌嗪,产率约为52%,并通过ESI-LC1、HNMR和元素分析对其进行了表征;该化合物再进一步还原得到1-叔丁氧羰基-4-(4,5-二氨基-3-甲基苯基)哌嗪。该反应步骤少、路线短、收率高、成本低、条件温和。
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| 关 键 词： | 1-叔丁氧羰基-4-（4，5-二氨基-3-甲基苯基）哌嗪 医药中间体 合成 |
Synthesis of tert-Butyl 4-(4,5-diamino-3-methylphenyl)piperazine-1-carboxylate |
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| GUO Li-min.Synthesis of tert-Butyl 4-(4,5-diamino-3-methylphenyl)piperazine-1-carboxylate[J].Chemistry & Bioengineering,2010,27(2):23-25. |
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| Authors: | GUO Li-min |
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| Abstract: | tert-Butyl 4-(4,5-diamino-3-methylphenyl)piperazine-1-carboxylate was obtained through reduction reaction of tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)piperazine-1-carboxylate that was synthesized through one-step amination of 4-iodo-2-methyl-6-nitroaniline with CuI as catalyst,ethylene glycol as catalyst ligand,potassium phosphate as alkaline medium,isopropanol as solvent.The process got high yield under mild conditions with low cost and simple operation. |
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