| 肝ASGP受体功能显像剂的制备及显像研究 |
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| 引用本文： | 张荣军,梁高林,万卫星,蔡刚明,叶万忠,陶永辉,张莲芬,谭成,金坚.肝ASGP受体功能显像剂的制备及显像研究[J].核技术,2000,23(11):780-785. |
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| 作者姓名： | 张荣军 梁高林 万卫星 蔡刚明 叶万忠 陶永辉 张莲芬 谭成 金坚 |
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| 作者单位： | 核医学国家重点实验室，江苏省原子医学研究所 无锡214063 |
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| 摘 要： | 采用ＦＰＬＣ快速纯化人血清白蛋白，利用双功能试剂２－亚胺基－２－甲氧基乙基－１－硫代－半乳糖甙与伯胺基的成脒反应，将工半乳糖残基引入人血清白蛋白分子，得到平均糖密度为３０的新半乳糖人血清白蛋白（ＮＧＡ）；用直接法制备＾９９ｍＴｃ－ＮＧＡ，其放化纯大于９０％，且室温下可稳定６ｈ以上，符合显像要求。＾９９ｍＴｃ－ＮＧＡ小鼠体内分布实验及大鼠、兔和狗的显像研究均表明＾９９ｍＴｃ－ＮＧＡ能够被肝脏特异摄取
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| 关 键 词： | 锝^99m标记 NGA 肝ASGP受体功能显像剂 |
| 修稿时间： | 1999年6月30日 |
Preparation and imaging study of a hepatic receptor imaging agent |
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| Zhang Rongjun,Liang Gaolin,WAN Weixing,CAI Gangming,YIE Wanzhong,TAO Yonghui,Zhang Lianfeng,Tan Chen,JIN Jian.Preparation and imaging study of a hepatic receptor imaging agent[J].Nuclear Techniques,2000,23(11):780-785. |
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| Authors: | Zhang Rongjun Liang Gaolin WAN Weixing CAI Gangming YIE Wanzhong TAO Yonghui Zhang Lianfeng Tan Chen JIN Jian |
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| Abstract: | Human serum albumin (HSA) was purified by FPLC with HiTrap Q column. Galactosyl neoglycoalbumin (NGA) was synthesized by the cova lent coupling of a bifunctional reagent, 2-imino-2-ethyloxymethyl-1-thiogalactose, to HSA. The average number of galactose groups was 30 in each NGA . NGA was labeled directly with Na99mTcO4. The radiochemical purity of 99mTc-NGA was over 90%. Biodistribution in mice, liver imaging in rat, rabbit and dog all show that 99mTc-NGA is a good hepatic receptor imaging agent. |
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| Keywords: | A 99mTc Hepatic receptor imaging agent Bifunctional reagent |
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