布托啡诺、哌替啶与曲马多治疗围麻醉期病人寒战的效果

目的: 观察布托啡诺、哌替啶与曲马多三种药物治疗围麻醉期病人寒战的效果。方法: 60例ASAⅠ~Ⅱ级麻醉期间发生寒战反应的病人,随机分为三组,每组20例:布托啡诺组,静脉注射布托啡诺 0.02 mg/kg;哌替啶组,静脉注射哌替啶 0.5mg/kg;曲马多组,静脉注射曲马多 1 mg/kg。观察寒战程度及治疗效果,用药后镇静评分及不良反应。结果: 布托啡诺组和曲马多组寒战治疗有效率高于哌替啶组(P<0.01);哌替啶组和曲马多组的镇静评分显著高于布托啡诺组(P<0.05);曲马多组恶心呕吐发生率高于哌替啶组和布托啡诺组(P<0.05)。结论: 布托啡诺与曲马多可有效控制麻醉后的寒战反应,但布托啡诺镇静作用较强,而曲马多增加恶心呕吐发生率,临床上应根据患者的情况合理应用相应药物。

A comparison among butorphanol,pethidine and tramadol in treating perioperative chilling

AIM: To study the effects of butorphanol , pethidine and tramadol in treatment of patients with perioperative shivering. METHODS: Sixty ASAⅠ-Ⅱ patients with shivering response during anesthesia were randomly divided into three groups(n=20): butorphanol group (group B), intravenous injection of butorphanol 0.02 mg/kg; pethidine group (group P), intravenous injection of pethidine 0.5 mg/kg; and tramadol group (group T), intravenous tramadol 1 mg/kg. Observed the degree and time of occurrence of shivering, shivering response after treatment and adverse effect in sedation score. RESULTS: Butorphanol group and tramadol group were effective than pethidine group in treatment of shivering(P<0.01). Butorphanol group was significantly higher than tramadol group and pethidine group in sedation(P<0.05).Tramadol group was significantly higher than pethidine group and butorphanol group in incidence of nausea and vomiting(P<0.05).CONCLUSION: Butorphanol and tramadol can effectively treat perioperative shivering,but clinical patients should be reasonable select different drugs according to particular case.