铂类药物神经毒性的药物基因组学研究进展

铂类药物广泛的应用于肺癌、大肠癌、卵巢癌、乳腺癌等多种癌症的治疗。然而,铂类药物的疗效往往由于严重的毒副反应,尤其是神经毒性而受到限制。铂类药物的神经毒性存在较大的个体性差异,其药物代谢相关基因的遗传变异是导致神经毒性个体差异的重要原因之一。本文就铂类药物转运体、药物代谢酶和DNA修复酶等相关基因的遗传多态性与铂类药物神经毒性之间的相关性作一综述。

Advances in pharmocogenetics of platinum neurotoxicity

Platinum-based drugs are widely used to treat lung cancer, colorectal cancer, ovarian cancer, breast cancer and other cancers. However, the efficacy of platinum drugs are often restricted due to many serious side effects, especially neurotoxicity. There is a large of interindividual variability in platinum-based drugs induced neurotoxicity. It is thought that drug metabolism-related genetic mutation is one of the important reasons. This review summarizes the relationship between the polymorphisms of genes encoding platinum-based drug transporters, platinum-based drug-metabolizing enzymes and DNA repair enzymes and neurotoxicity of platinum-based drugs.