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| 伊班膦酸钠的合成研究 | |
| 引用本文： | 赵凯,侯建平,简勇学,周彦峰,钟云梅.伊班膦酸钠的合成研究[J].应用化工,2011,40(3). |
| 作者姓名： | 赵凯 侯建平 简勇学 周彦峰 钟云梅 |
| 作者单位： | 1. 河北凯盛医药科技有限公司,河北,石家庄,050091;江西欧氏药业有限责任公司,江西,新余,338004 2. 河北凯盛医药科技有限公司,河北,石家庄,050091 3. 江西欧氏药业有限责任公司,江西,新余,338004 |
| 摘 要： | 以正戊胺为起始原料合成了N-甲基正戊胺(3),化合物(3)与丙烯酸甲酯经过缩合和水解制得3-(N-甲基戊胺基)-丙酸盐酸盐(2),化合物(2)在无溶剂的情况下膦酸化和中和反应合成了伊班膦酸钠(1),总收率36.6%,其产品结构经1H NMRI、R、MS表征。该工艺具有原料易得,收率高,质量好,对环境污染小等特点。 |
| 关 键 词： | 伊班膦酸钠 正戊胺 合成 |
Study on the synthesis of sodium ibandronate |
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| ZHAO Kai,HOU Jian-ping,JIAN Yong-xue,ZHOU Yan-feng,ZHONG Yun-mei.Study on the synthesis of sodium ibandronate[J].Applied chemical industry,2011,40(3). | |
| Authors: | ZHAO Kai HOU Jian-ping JIAN Yong-xue ZHOU Yan-feng ZHONG Yun-mei |
| Affiliation: | ZHAO Kai1,2,HOU Jian-ping1,JIAN Yong-xue2,ZHOU Yan-feng1,ZHONG Yun-mei2(1.Hebei Kingsci Pharmaceutical Technology Co.,Ltd.,Shijiazhuang 050091,China,2.Jiangxi Ourshi Pharmaceutical Co.,Xinyu 338004,China) |
| Abstract: | Sodium ibandronate(1) in total yield of 36.6% was synthesized in without solvent by phosphorylation and neutralization of 3-(N-methylentylamino)propionic acid hydrochloride(2) which was prepared by condensation and hydrolysis from methyl acrylate with N-methylpentylamine(3) produced by the reaction of pentyamine.The structure of(1) was confirmed by 1H NMR,IR,MS.It has characteristics of ready availability of reactant,high yield,good quality,little pollution to environment. |
| Keywords: | sodium ibandronate pentyamine synthesis |
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