| 接枝层厚度对聚(N-异丙基丙烯酰胺)改性表面与蛋白质相互作用的影响 |
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| 引用本文： | 于谦,张燕霞,徐亚骏,陈红.接枝层厚度对聚(N-异丙基丙烯酰胺)改性表面与蛋白质相互作用的影响[J].材料导报,2010,24(22). |
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| 作者姓名： | 于谦 张燕霞 徐亚骏 陈红 |
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| 作者单位： | 武汉理工大学材料科学与工程学院,武汉,430070;苏州大学材料与化学化工学部,苏州,215123;武汉理工大学材料科学与工程学院,武汉,430070;苏州大学材料与化学化工学部,苏州,215123 |
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| 摘 要： | 采用表面引发原子转移自由基聚合(ATRP)的方法制备了聚(N-异丙基丙烯酰胺)(PNIPAAm)改性表面,通过改变聚合时间进而调控表面接枝层厚度.水接触角和蛋白质吸附测试发现PNIPAAm改性表面的浸润性和对蛋白质吸附都具有一定的温度响应性,且随着PNIPAAm接枝层厚度的增加,该温度响应性有一定程度的增强.同时,纤维蛋白原和溶菌酶的吸附测试表明PNIPAAm改性表面对尺寸不同的蛋白质具有不同的温度响应性.
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| 关 键 词： | 聚(N-异丙基丙烯酰胺) 温度响应性 蛋白质吸附 厚度 |
Influence of the Grafted Layer Thickness on the Interaction between Poly (N-isopropylacrylamide) Modified Surfaces and Proteins |
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| YU Qian,ZHANG Yanxia,XU Yajun,CHEN Hong.Influence of the Grafted Layer Thickness on the Interaction between Poly (N-isopropylacrylamide) Modified Surfaces and Proteins[J].Materials Review,2010,24(22). |
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| Authors: | YU Qian ZHANG Yanxia XU Yajun CHEN Hong |
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| Affiliation: | YU Qian1,2,ZHANG Yanxia1,XU Yajun2,CHEN Hong2(1 School of Materials Science and Engineering,Wuhan University of Technology,Wuhan 430070,2 College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123) |
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| Abstract: | The poly(N-isopropylacrylamide)(PNIPAAm) brushes are prepared via surface-initiated atom transfer radical polymerization(SI-ATRP) on initiator-immobilized silicon surfaces.The thickness of grafted PNIPAAm layer is modulated by adjusting polymerization time.The PNIPAAm modified surface exhibits thermo-responsivity to both wettability and protein adsorption in some extent and the thermo-responsivity is enhanced as the thickness of PNIPAAm layer increases.Moreover,the adsorption results of two proteins(fibrino... |
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| Keywords: | poly(N-isopropylacrylamide) thermo-responsivity protein adsorption thickness |
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