Self-assembled sponge-like hydroxyapatite induced by modified articular cartilage membrane template |
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| Authors: | Xun Liu Yaxin Zheng Yongjun Ma Tingting Huo Chonghua Pei |
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| Affiliation: | 1. State Key Laboratory of Environment-friendly Energy Materials, Southwest University of Science and Technology, Mianyang 621010, PR China;2. Analytical and Testing Center, Southwest University of Science and Technology, Mianyang 621010, PR China;3. Key Laboratory of Solid Waste Treatment and Resource Recycle, Ministry of Education, Southwest University of Science and Technology, Mianyang 621010, PR China |
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| Abstract: | Using modified pig bone articular cartilage membrane as template, a sponge-like hydroxyapatite (HA) scaffold material was in-situ synthesized by self-assembly in simulated body fluid. Its crystallographic structure and composition were studied by SEM, XRD, FTIR and TEM, which showed that the synthesized sample was carbonated HA crystals and the three-dimensional interconnected sponge-like structure consists of massive nano hydroxyapatite plates. The physicochemical properties of the samples were tested and the results indicated that the sponge-like HA had high density, porosity and specific surface. Experimental cell culture results also showed that sponge-like HA greatly increases the bioactivity, osteoconductivity and differentiation of human osteosarcoma MG-63 cells. |
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| Keywords: | Articular cartilage membrane Apatite (D) Porosity (B) Biomedical applications (E) |
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