|
|||||
|
|
| 大豆多肽对小鼠急性肝损伤保护作用的研究 | |
| 引用本文： | 戚颖欣,孟 军,曹柏营,昌友权,苏 伟. 大豆多肽对小鼠急性肝损伤保护作用的研究[J]. 食品科学, 2009, 30(21): 377-379. DOI: 10.7506/spkx1002-6300-200921089 |
| 作者姓名： | 戚颖欣 孟 军 曹柏营 昌友权 苏 伟 |
| 作者单位： | 1.吉林工程技术师范学院食品工程学院 2.吉林省通化市食品药品检验所 |
| 基金项目： | 吉林省科技发展计划项目(20080131) |
| 摘 要： | 采用CCl4 灌胃造成小鼠急性肝损伤模型，将大豆多肽分为高、中、低剂量组，分别为3、1.8、0.6g/kg·d喂饲小鼠30d，观察其对血清GPT、GOT 和ALP 及肝脏TG、TC、MDA 和GSH 的影响。实验结果表明：成功建立小鼠急性肝损伤模型，与模型组比较，大豆多肽可显著降低血清中GOT、GPT 和ALP 活性和肝脏TG、TC和MDA 含量，提高肝脏中GSH 含量，以高剂量组效果最佳，呈明显的剂量依赖性。大豆多肽对CCl4 引起的小鼠急性肝损伤具有保护作用。 |
| 关 键 词： | 大豆多肽 肝损伤 谷丙转氨酶 谷草转氨酶 碱性磷酸酶(ALP) 丙二醛(MDA) 谷胱甘肽 |
| 收稿时间： | 2009-07-01 |
Protective Effect of Soybean Polypeptides on Acute Liver Injury in Mice |
|
| QI Ying-xin,MENG Jun,CAO Bai-ying,CHANG You-quan,SU Wei. Protective Effect of Soybean Polypeptides on Acute Liver Injury in Mice[J]. Food Science, 2009, 30(21): 377-379. DOI: 10.7506/spkx1002-6300-200921089 | |
| Authors: | QI Ying-xin MENG Jun CAO Bai-ying CHANG You-quan SU Wei |
| Affiliation: | 1. College of Food Engineering, Jilin Teachers’Institute of Engineering and Technology, Changchun 130052, China ；2. Tonghua Food and Drug Administration of Jilin, Tonghua 134000, China |
| Abstract: | Mice with acute liver injury were modeled through CCl4 induction and orally administered with soybean polypeptides at doses of 3, 1.8 and 0.6 g/kg·d for 30 d, respectively. Effects of soybean polypeptides on glutamic-oxaloacetic transminase (GOT), glutamic-pyruvic transminase (GPT) and alkaline phosphataes (ALP) in serum and triglyceride (TG), total cholesterol (TC), malondialdehye (MDA) and glutathione peroxidase (GSH) levels in liver were investigated. Results indicated that CCl4- induced mice model with liver injury was successfully established. Soybean polypeptides significantly decreased the levels of GOT, GPT and AST in serum and TG, TC and MDA in liver, and obviously increased the level of GSH in liver in a dosedependent manner. Therefore, soybean polypeptides have an excellent protective capability against acute liver injury in mice induced by CCl4. |
| Keywords: | soybean polypeptides liver injury GPT GOT ALP MDA GSH |
| 点击此处可从《食品科学》浏览原始摘要信息 | |
| 点击此处可从《食品科学》下载全文 | |