Chiral Scandium‐Catalysed Enantioselective Ring‐Opening of meso‐Epoxides with N‐Heterocycle,Alcohol and Thiol Derivatives in Water

In the presence of catalytic amounts of Sc(OSO₃C₁₂H₂₅)₃ and a chiral bipyridine ligand, asymmetric ring‐opening of meso‐epoxides with aromatic N‐heterocycles, an alcohol and thiols proceeded smoothly to afford the corresponding products in moderate to good yields (34–85 %) with high to excellent enantioselectivities (74–96 % ee). Water was used as the sole and essential solvent in these important enantioselective transformations.