Isolation of translactone-containing triterpenes with thrombin inhibitory activities from the leaves of Lantana camara |
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| Authors: | MJ O'Neill JA Lewis HM Noble S Holland C Mansat JE Farthing G Foster D Noble SJ Lane PJ Sidebottom SM Lynn MV Hayes CJ Dix |
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| Affiliation: | GlaxoWellcome Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK. mjon7483@glaxowellcome.co.uk |
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| Abstract: | Methanolic extracts prepared from the leaves of Lantana camara have been found to inhibit human thrombin. An assay, in which thrombin activity is measured as a function of clot formation from fibrinogen, was used to guide the fractionation and purification of five principal active constituents (1-5), which were all characterized as 5,5-trans-fused cyclic lactone-containing euphane triterpenes. |
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