流行性出血热灭活疫苗对同型和异型病毒的抗体应答

本文对 Z_(10)株出血热活病毒及其灭活疫苗免疫动物或人体后,对同型(野鼠型—血清Ⅰ型)和异型(家鼠型—血清Ⅱ型)病毒的抗体应答进行了试验比较。结果表明,经活毒或疫苗免疫后的家兔,对同型病毒产生的中和及血抑抗体高于对异型病毒的4～8倍。10名自愿者经 Z_(10)株灭活疫苗免疫后,血清的中和及血抑抗体阳转率对同型病毒均为90%,而对异型病毒仅为20～30%。以上结果证实我国野鼠型和家鼠型病毒间的抗原性差异。提示制备二型双价疫苗及筛选对二型均有保护作用的生产用毒株的必要性。

Antibody Responses of Inactivated HFRS Vaccine to Homologous and Heterologous Types of Virus

The antibody responses of HFRS Z_(10) virus and its vaccines to homologous andheteroiogous types of viruses were studied.The results revealed that rabbits immunized withboth live virus and inactivated vaccine elicited neutralizing and HI antibodies to homo-logous viruses ranging from 4 to 8 fold higher than the antibodies to heterologous viruses.10 volunteers vaccinated with the Z_(10) inactivated vaccine showed higher NT and HI anti-bodies to the homologous virus and the seroconversion rates to the homologous virus was 90%(both NT and HI antibodies),but to the heteroiogous otis viruses only 20～30%.This results provided the evidence of antigenic difference between apodemus-type andrattus-type HFRS viruses.It also suggested the necessities of developing bivalent vaccinewith the two sero-types of viruses or selecting an antigenically broad virus strain as a can-didate vaccine virus strain.