Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors |
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| Authors: | M Perez PJ Pauwels I Pallard-Sigogneau C Fourrier P Chopin C Palmier V Colovray S Halazy |
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| Affiliation: | Medicinal Chemistry, Centre de Recherche Pierre Fabre, Castres, France. michel.perez@pierre-fabre.com |
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| Abstract: | ![]()
Hybrid molecules built up by covalent coupling of aminopropanol derivatives (especially pindolol) with antidepressant drugs like fluoxetine, paroxetine or milnacipran were found to be potent and silent 5-HT1A antagonists (KB < 1 nM for 7c and 9a). |
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