| NMDA 受体亚型与神经病理性疼痛关系的研究进展 |
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| 引用本文： | 官文芳,;祝高春,;刘曾旭. NMDA 受体亚型与神经病理性疼痛关系的研究进展[J]. 矿产勘查, 2014, 0(5): 87-89 |
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| 作者姓名： | 官文芳, 祝高春, 刘曾旭 |
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| 作者单位： | [1]南昌大学基础医学院解剖学教研室,南昌330006; [2]宜春职业技术学院护理学院内科教研室,江西宜春336000 |
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| 基金项目： | 国家自然科学基金（81260190）;江西省自然科学基金（20132BAB205023） |
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| 摘 要： | N-甲基-D-天门冬氨酸（N-methyl-D-aspartate,NMDA）受体是谷氨酸离子型受体（iGluRs）的一个亚型,由NR1、NR2（A、B、C和D）和 NR3（A、B）7种亚单位组成。NMDA受体的多种亚型与神经病理性疼痛有密切的关系,目前研究与开发的重点是如何应用针对 NMDA受体不同亚型的拮抗剂来治疗神经病理性疼痛。
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| 关 键 词： | NMDA受体 谷氨酸受体 谷氨酸离子型受体 神经病理性疼痛 治疗 |
Advances in Relationship between NMDA Receptor Subtypes and Neuropathic Pain |
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| Affiliation: | GUAN Wen-fang, ZHU Gao-chun, LIU Zeng-xu (1.Department of Anatomy ,Basic Medical School of Nanchang University, Nanchang 330006, China; 2. Department of Internal Medicine, Nursing School of Yichun Vocation Technical College ,Yichun 336000,China) |
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| Abstract: | N-methyl-D-aspartate（NMDA）receptor is a subtype of ionotropic glutamate recep-tors（iGluRs）.NMDA receptor consists of 7 subunits,NR1,NR2（A,B,C,D）and NR3（A,B）.Re-cent studies have found that there is a close relationship between NMDA receptor subtypes and neuropathic pain.The research and development of peptide antagonists that target NMDA recep-tor subtypes are the focus of the treatment of neuropathic pain. |
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| Keywords: | NMDA receptor glutamate receptor ionotropic glutamate receptors neuropathic pain therapy |
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