| Peptides radiolabeled with Re-186/188 and Tc-99m as potential diagnostic and therapeutic agents |
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| 引用本文： | E. GARCIA-GARAYOA R. SCHIBLI RA. SCHUBIGER. Peptides radiolabeled with Re-186/188 and Tc-99m as potential diagnostic and therapeutic agents[J]. 核技术(英文版), 2007, 18(2): 88-100. DOI: 10.1016/S1001-8042(07)60026-8 |
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| 作者姓名： | E. GARCIA-GARAYOA R. SCHIBLI RA. SCHUBIGER |
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| 作者单位： | [1]Center for Radiopharmaceutical Science of the ETH Zurich-Paul Scherrer lnstitut-University Hospital Zurich, CH-5232, VHligen PSI, Switzerland [2]Department of Chemistry and Applied Biosciences ETH Zurich, 8093 Zurich, Switzerland |
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| 基金项目： | Acknowledgments We thank Christian Schweinsberg for helping to prepare this review article. |
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| 摘 要： | Small peptide-based compounds have attracted an enormous interest as carrier molecules to selectively deliver radionuclides to target tissues, sparing critical normal organs. When looking for ＂matched pairs＂ of radionuclides, suitable for radiolabeling of peptides for diagnosis and therapy, technetium and rhenium represent an almost ideal constellation. The important role of technetium-99m and Re-186/188 is based on the decay characteristics, suitable for tumor diagnosis and therapy. Tc-99m and Re-188 are readily available by either a ^99Mo/^99mTc or the ^188w/^188Re radionuclide generator system Furthermore, technetium and rhenium are chemically related and share structural as well as reactive similarities, which prompt an attractive ＂matched-pair＂ situation. This article shows an overview of ^99mTc- and ^186/188Re-radiolabeled peptides that have been tested for their potential use as imaging and therapeutic agents in oncological diseases.
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| 关 键 词： | 放射性同位素标记肽类 铼186/188 锝99m 诊断药物 治疗药物 |
| 收稿时间： | 2006-12-20 |
Peptides radiolabeled with Re-186/188 and Tc-99m as potential diagnostic and therapeutic agents |
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| Affiliation: | 1. Department of General Surgery, Mayo Clinic Jacksonville, FL, USA;2. Department of Biostatistics, Mayo Clinic Jacksonville, FL, USA;3. Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic Jacksonville, FL, USA |
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| Abstract: | Small peptide-based compounds have attracted an enormous interest as carrier molecules to selectively deliver radionuclides to target tissues, sparing critical normal organs. When looking for “matched pairs” of radionuclides, suitable for radiolabeling of peptides for diagnosis and therapy, technetium and rhenium represent an almost ideal constellation. The important role of technetium-99m and Re-186/188 is based on the decay characteristics, suitable for tumor diagnosis and therapy. Tc-99m and Re-188 are readily available by either a 99Mo/99mTc or the 188W/188Re radionuclide generator system. Furthermore, technetium and rhenium are chemically related and share structural as well as reactive similarities, which prompt an attractive “matched-pair” situation. This article shows an overview of 99mTc-and 186/188Re-radiolabeled peptides that have been tested for their potential use as imaging and therapeutic agents in oncological diseases. |
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| Keywords: | Radiolabeled peptides Imaging Therapy Oncology Technetium-99m Rhenium-186/188 |
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