Steric requirements for the stimulation of glycosyltransferase activity by lysophosphatidylcholine |
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| Authors: | P. J. A. O’Doherty |
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| Affiliation: | (1) G.F. Strong Laboratory for Medical Research, Department of Medicine, University of British Columbia, V5Z 1M9 Vancouver, British Columbia, Canada |
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| Abstract: | 1-Palmitoyl-sn-glycerol-3-phosphocholine and 3-palmitoyl-sn-glycerol-1-phosphocholine have been found to be equipotent in the stimulation of membrane-bound glycosyltransferases in microsomes of rat intestinal villus cells. This indicates that the stimulatory effect of lysophosphatidylcholine is not stereospecific, but that it may be related to a specific detergent property dependent upon the peculiar balance of hydrophilic and hydrophobic components in the molecule. |
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