| 功能化SBA-15在药物阿司匹林缓释的动力学模型 |
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| 引用本文： | 张晓彤,梁俊虎,任创,葛翠年,段林海,宋丽娟.功能化SBA-15在药物阿司匹林缓释的动力学模型[J].石油化工高等学校学报,2012,25(2):1-4. |
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| 作者姓名： | 张晓彤 梁俊虎 任创 葛翠年 段林海 宋丽娟 |
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| 作者单位： | 辽宁石油化工大学辽宁省石油化工重点实验室,辽宁抚顺,113001 |
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| 基金项目： | 国家自然科学基金，辽宁省教育厅资助项目 |
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| 摘 要： | 采用两种介孔分子筛(SBA-15和SBA-15-NH2)分别对水溶性药物阿司匹林进行药物吸附与释放的对比研究,利用FT-IR,UV等手段对样品结构、药物装载和释放过程进行表征。同时,运用Korsmeyer-Pep-pas和Higuchi模型分别对药物缓释体系进行动力学研究。结果表明,氨基改性后SBA-15对阿司匹林的吸附量由14.2%提高到19.5%,且释放时间更长。SBA-15-ASP缓释系统的释放动力学过程遵循Fick扩散机理,而SBA-15-NH2-ASP释放过程遵循非Fick扩散机理。
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| 关 键 词： | SBA-15 阿司匹林 药物缓释 动力学模型 |
Release Kinetic Model Studies of Functionalized Mesoporous Materials SBA-15 as Aspirin Carriers |
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| ZHANG Xiao-tong
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LIANG Jun-hu
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REN Chuang
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GE Cui-nian
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DUAN Lin-hai
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SONG Li-juan.Release Kinetic Model Studies of Functionalized Mesoporous Materials SBA-15 as Aspirin Carriers[J].Journal of Petrochemical Universities,2012,25(2):1-4. |
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| Authors: | ZHANG Xiao-tong LIANG Jun-hu REN Chuang GE Cui-nian DUAN Lin-hai SONG Li-juan |
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| Affiliation: | *(Liaoning Key Laboratory of Petrochemical Engineering,Liaoning Shihua University,Fushun Liaoning113001,P.R.China) |
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| Abstract: | Mesoporous materials SBA-15and SBA-15-NH 2 were investigated as the water-insoluble aspirin carrier for controlled drug delivery.The samples structure,drug loading and release profiles were characterized by means of Fourier transform infrared spectroscopy(FT-IR) and UV-spectrophotometer(UV),meantime the release kinetics were analyzed using following mathethematical models Korsmeyer-Peppas equation and Higuchi equation.The results show that the adsorption capacity and release properties of SBA-15for drug molecules can be improved by functionalizing its surfaces with amine groups,the adsorption of aspirin from 14.2%to 19.5%.The release process of SBA-15-Aspirin follow a Fickian diffusion mechanism,and SBA-15-NH 2-Aspirin follow a Non-Fickian diffusion mechanism. |
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| Keywords: | SBA-15 Aspirin Drug delivery Kinetic model |
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