| 4-丙硫基-2-硝基苯胺CO选择还原合成-4-丙硫基邻苯二胺 |
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| 引用本文： | 蒋景阳,缪强,李大勇,金子林.4-丙硫基-2-硝基苯胺CO选择还原合成-4-丙硫基邻苯二胺[J].精细化工,2003,20(7):437-439. |
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| 作者姓名： | 蒋景阳 缪强 李大勇 金子林 |
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| 作者单位： | 大连理工大学,精细化工国家重点实验室,辽宁,大连,116012 |
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| 基金项目： | 辽宁省自然科学基金(2001101067) |
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| 摘 要： | 首次将Ru3(CO)9(TPP)3配合物催化剂用于4 丙硫基 2 硝基苯胺(Ⅰ)的CO选择还原反应,考察了反应条件对反应转化率和选择性的影响。PCO=5 0MPa,θ=140℃,t=20h,n(Ⅰ)/n(Ru)=300的反应条件下,转化率为83%,选择性达98%,为合成高效广谱驱虫药阿苯达唑(Albendazole)关键中间物4 丙硫基邻苯二胺提供了一条环境友好新路线。
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| 关 键 词： | CO选择还原 钌-膦催化剂 4-丙硫基-2-硝基苯胺 |
| 文章编号： | 1003-5214(2003)07-0437-03 |
Synthesis of 4-Propylthio-o-phenylenediamine by CO Selective Reduction of 4-Propylthio-2-nitroaniline |
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| Abstract: | Ru3(CO)9(TPP)3 complex catalyst was applied for the first time to the selective reduction of 4 propylthio 2 nitroaniline(Ⅰ) using CO as reductant.Effects of reaction conditions on the conversion and selectivity was systematically investigated.Under the conditions of PCO=50 MPa,θ=140 ℃,t=20 h,n(Ⅰ)/n(Ru)=300,the conversion and selectivity reached up to 83% and 98% respectively.The results provided a novel environmentally-friendly approach for the systhesis of 4 propylthio o phenylenediamine,which is the key intermediate of an effective and widely used parasiticide Albendazole. |
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| Keywords: | CO selective reduction Ru-phosphine catalyst 4-propylthio-2-nitroaniline |
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