| 手性助剂樟脑磺酸酯的合成工艺研究 |
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| 引用本文： | 刘秀娟,王歌云,厉连斌.手性助剂樟脑磺酸酯的合成工艺研究[J].化学世界,2012,53(5):300-302. |
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| 作者姓名： | 刘秀娟 王歌云 厉连斌 |
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| 作者单位： | 江西教育学院理学分院,江西南昌,330029 |
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| 基金项目： | 江西省教育厅科技计划项目(赣教科技便函字2002-01) |
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| 摘 要： | 以樟脑磺酸为起始原料,通过两步反应,合成了樟脑磺酸酯,并用IR和1 H NMR进行了表征。优化条件为:n(樟脑磺酰氯)∶n(甲醇)∶n(吡啶)=1.0∶2.5∶4.0,在-5℃下反应2h,樟脑磺酸甲酯的收率达到了73.2%,产品质量分数为99.6%。
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| 关 键 词： | 樟脑磺酸甲酯 樟脑磺酸乙酯 樟脑磺酰氯 樟脑磺酸 手性助剂 |
Studies on Synthesis of Camphor Sulfonate as Chiral Auxiliary |
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| LIU Xiu-juan
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WANG Ge-yun
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LI Lian-bin.Studies on Synthesis of Camphor Sulfonate as Chiral Auxiliary[J].Chemical World,2012,53(5):300-302. |
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| Authors: | LIU Xiu-juan WANG Ge-yun LI Lian-bin |
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| Affiliation: | (Science Department,Jiangxi Educational Institution,Jiangxi Nanchang 330029,China) |
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| Abstract: | Camphor sulfonate was synthesized from camphor sulfoacid by two steps reaction and was charactrized by IR and 1H NMR.The optimum reaction conditions were as follows: n(camphor sulfonyl chloride)∶n(methyl alcohol)∶n(pyridine)=1.0∶2.5∶4.0,reaction temperature-5℃ and reaction time 2 h.The yield of methyl camphor sulfonate was 73.2% with 99.6% purity. |
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| Keywords: | methyl camphor sulfonate ethyl camphor sulfonate camphor sulfonyl chloride camphor sulfoacid chiral auxiliary |
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