FeNi@SiO2磁性纳米复合粒子的制备及磁热性能

大量制备磁热性能优异的磁性纳米粒子对磁热疗和组织复温的生物学应用具有理论价值.本研究通过高温电弧法制备FeNi磁性纳米颗粒,通过超声-沉降分级筛分得到平均粒径为80 nm的FeNi纳米颗粒,通过溶胶-凝胶法得到平均粒径为100 nm,SiO2壳层厚度为15～20 nm的FeNi@SiO2纳米复合粒子.超导量子干涉仪测定FeNi@SiO2纳米复合粒子饱和磁化强度Ms为80 emu/g.模拟磁热疗条件下,FeNi@SiO2磁性纳米粒升温速率为3.6℃/min,满足磁热疗应用要求.模拟组织复温条件下,FeNi@SiO2磁性纳米粒升温速率为61.8℃/min.磁性复合纳米粒子在不同溶剂、不同温区条件都显示了良好的热性能,可作为温度激活剂应用于磁热疗及冷冻组织的复温.本研究对磁性纳米材料的生物学应用研究具有一定的参考价值.

Synthesis and Magnetocaloric Effects of FeNi@SiO2 Nanocomposite Particles

Large-scale synthesis and prominent magnetocaloric effects of magnetic particles in low temperature and normal temperature ranges have theoretical value for the application of tissue rewarming and magnetic hyperthermia.Iron-nickel nanoparticles with an average diameter of 80nm were prepared on a large scale by high-temperature arc discharge method following the process of classification and sedimentation.Iron-nickel silica nanoparticles with an average diameter of 100 nm were obtained by the sol-gel method and the coating thickness was 15-20 nm.The saturation magnetization (Ms ) was measured to be 80 emu/g by using a superconducting quantum interferometer.Under the high-temperature standard,the iron-nickel silica nanoparticles mainly show the magnetocaloric effect,and the average heating rate is 3.6 ℃/min,which is enough to consider the need for magnetic hyperthermia.In the simulation condition of tissue rewarming,iron-nickel silica nanoparticles exhibit prominent magnetocaloric efficiency with an average heating rate of 61.8 ℃/min in the presence of Vs55 . The iron-nickel silica nanocomposite particles exhibit prominent magnetocaloric effects in different solvents and temperature ranges so that they can be used as a temperature activating agent for tissue rewarming and hyperthermia.The results benefit the applications of hyperthermia and tissue rewarming.