基于纳米锥森林的三维SERS基底检测miRNA

表面增强拉曼散射(SERS)是一种从存在于不同化学或生物环境中的分子中获取振动信息的强大技术。本文提出了一种基于纳米锥森林结构的三维SERS基底。制备基板采用等离子体处理技术,这项技术是一种简单、快速和高通量的方法。制备的基于纳米锥森林的SERS基底具有很高的灵敏度。实验表明,该基底可以检测到浓度低至10-10 M的miRNA。同时,所制备的SERS基底在大面积上表现出高度的均匀性。这些实验结果表明该3D SERS基底在广泛应用中的巨大潜力。

3D SERS substrate based on nanocone forests for miRNA detections

Surface-enhanced Raman scattering (SERS)is a powerful technology for obtaining vibrational information from molecules that present in different chemical or biological environments.This paper presents a 3D SERS substrate based on nanocone forests.The substrates are prepared by using plasma treatment technique,which is a simple,fast and high-throughput approach.The SERS substrate based on nanocone forests exhibits high sensitivity.In the experiment,miRNA with a concentration as low as 10-10 M can be achieved.Meanwhile,the proposed SERS substrate shows a high uniformity over a large area.These experimental results demonstrate great potential of the 3D SERS substrate in wide applications.