| 硫化氢在组织修复和再生中的研究进展 |
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| 引用本文： | 武俊池,于楠楠,赵程程,刘文辉,罗芝英,蔡骅琳,刘艺平.硫化氢在组织修复和再生中的研究进展[J].金属学报,2022,27(2):235-240. |
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| 作者姓名： | 武俊池 于楠楠 赵程程 刘文辉 罗芝英 蔡骅琳 刘艺平 |
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| 作者单位： | 1.中南大学湘雅药学院，2中南大学湘雅二医院药学部，长沙 410011，湖南 |
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| 基金项目： | 湖南省自然科学基金（2021JJ80081） |
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| 摘 要： | 硫化氢（H2S）是一种无色、有臭鸡蛋味的气体，是人体最重要的生物信号分子。H2S在体内经酶催化和非酶途径产生，生理浓度的H2S对人体是有益的，内源性的H2S具有抗氧化、炎症、调节细胞凋亡、血管舒张、降血压、神经调节和骨保护等作用。H2S参与了组织和器官的修复，未来可用于临床治疗。本文将就H2S在组织损伤中常见的修复和再生作用及其机制做一综述，有利于理解体内H2S的作用和新药的开发。
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| 关 键 词： | 硫化氢 组织损伤 修复再生 |
| 收稿时间： | 2021-04-06 |
| 修稿时间： | 2021-09-18 |
Research progress on hydrogen sulfide in tissue repair and regeneration |
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| WU Junchi,YU Nannan,ZHAO Chengcheng,LIU Wenhui,LUO Zhiying,CAI Hualin,LIU Yiping.Research progress on hydrogen sulfide in tissue repair and regeneration[J].Acta Metallurgica Sinica,2022,27(2):235-240. |
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| Authors: | WU Junchi YU Nannan ZHAO Chengcheng LIU Wenhui LUO Zhiying CAI Hualin LIU Yiping |
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| Affiliation: | 1.Xiangya School of Pharmaceutical Sciences, Central South University, 2Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China |
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| Abstract: | Hydrogen sulfide (H2S), a colorless gas with a strong odor of rotten eggs, is an important biological signaling molecule, which is produced in vivo through enzyme-catalyzed and non-enzymatic pathways. Physiological levels of H2S have systemic antioxidant, anti-inflammatory, regulating apoptosis, dilating blood vessels, lowering blood pressure, neuroprotective effects, and prevent bone damage. H2S plays an important role in tissue repair, which is of great value for clinical treatments. In this paper, the common repair and regeneration functions and mechanisms of hydrogen sulfide in tissue damage will be reviewed, which will be helpful to understand the role of H2S in vivo and the development of new drugs. |
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| Keywords: | hydrogen sulfide tissue damage repair and regeneration |
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