光固化生物陶瓷功能化研究进展EI北大核心CSCD

光固化制备陶瓷成为近年来快速发展的增材制造技术之一。生物陶瓷材料凭借良好的细胞相容性,在组织工程领域具有广阔前景,然而单一的生物陶瓷材料难以兼顾力学性能与生物相容性,其应用与推广受到极大限制。本文综述了适用于光固化的生物陶瓷材料改性及设计方法,重点讨论了材料改性、表面改性、结构设计以及微结构调控对于骨传导、骨诱导、抗菌、促进血管生成等生物性能及基础力学性能的综合影响,并指出通过改性及调控方法的组合探究多功能的实现及相互影响机理,能够充分实现光固化生物陶瓷的功能,推动其深层次应用。

Research progress in functionalization of photocured bioceramics

In recent years, photocured ceramics has become one of the rapidly developing additive manufacturing technologies. Bioceramics have a promising future in tissue engineering due to their good cellular compatibility, however, a single bioceramic material is difficult to take into account both mechanical properties and biocompatibility, so the application and promotion are greatly limited. In this paper, the modification and design methods of bioceramic materials suitable for photocuring were reviewed. The comprehensive effects of material modification, surface modification, structural design and microstructural regulation on the biological properties such as bone conduction, bone induction, antibacterial, angiogenesis promotion and other biological properties as well as and basic mechanical properties of were discussed. It was pointed out that the function of photocurable bioceramics can be fully realized and its further application can be promoted through the combination of modification and regulation methods, and the realization and interaction mechanism of multifunction should be explored.