316L不锈钢血管内支架表面Fe/Pd磁性膜的制备与生物学效应

以医用316L不锈钢血管支架为基体,采用电弧离子镀技术在其表面制备Fe/Pd磁性薄膜.通过激光扫描共焦显微镜、数字磁通磁场测量仪分析薄膜的表面形貌、表面粗糙度及表面磁性膜支架的磁性能,并通过动物体内实验研究Fe/Pd磁性膜支架的生物学效应.结果表明:Fe/Pd磁性膜支架表面光滑,并具有良好的生物学效应,显著地促进了血管内皮再生,同时有效地抑制了血管内膜过度增生和血管壁的炎症反应.

Preparation and Biological Effect of Fe/Pd Magnetic Film on Vascular Stent Surface

Fe/Pd magnetic films were prepared by vacuum arc ion plating technology on 316L stainless steel vascular stents. The surface morphology, the surface roughness and the magnetism of coated stents were characterized by laser scanning confocal microscope and digital magnetic flux and field measuring instruments, while the biological effects of the Fe/Pd coated magnetic stents were evaluated through animals experiment. The results show that the Fe/Pd coated magnetic stents, which are smooth and which have good biological compatibility, significantly promote vascular endothelium regeneration, and inhibit tunica intima thickening and vascular wall inflammatory