| 替考拉宁高产菌株的选育 |
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| 引用本文： | 张永红,吴军营,张志华,郄丽萍,田红.替考拉宁高产菌株的选育[J].河北化工,2011,34(5):31-32,59. |
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| 作者姓名： | 张永红 吴军营 张志华 郄丽萍 田红 |
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| 作者单位： | 华北制药集团新药研究开发有限责任公司,微生物药物国家工程研究中心,河北省工业微生物代谢工程技术研究中心,河北,石家庄,050015 |
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| 摘 要： | 以替考拉宁产生菌1-16为出发菌株,经热诱变复合替考拉宁抗性筛选高产菌株,获得一株高产突变菌株TC3-25,其替考拉宁产量较出发菌株提高46%。传代试验表明该菌株的发酵水平较稳定。
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| 关 键 词： | 替考拉宁 诱变 抗性筛选 |
Selection of the High-yield Strain of Teicoplanin |
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| ZHANG Yong-hong,WU Jun-ying,ZHANG Zhi-hua,QIE Li-ping,TIAN Hong.Selection of the High-yield Strain of Teicoplanin[J].Hebei Chemical Engineering and Industry,2011,34(5):31-32,59. |
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| Authors: | ZHANG Yong-hong WU Jun-ying ZHANG Zhi-hua QIE Li-ping TIAN Hong |
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| Affiliation: | (NCPC New Drugs R & D Co.,Ltd,National Engineering Research Center of Microbial Medicine,Hebei Industry Microbial Metabolic Engineering & Technology Research Center,Shijiazhuang 050015,China) |
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| Abstract: | Through treating teicoplanin producing strain 1-16 by heating,and screening the teicoplanin-resistant mutants,the high-yield mutant strain TC3-25 was obtained.The productivity of TC3-25 was 46% more than that of the parent strain1-16.Submerged culture indicated that the hereditary character of this high-yield strain was stable. |
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| Keywords: | teicoplanin mutagenesis resistant screening |
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