| ~(99m)Tc-标记尿激酶(血栓显像剂)的研制及动物实验 |
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| 引用本文： | 方瑞英,赵惠扬,刘文官,钱峰,陈可靖,冯友贤,杨国华,郑佳仅,范梅影,吴伯惠,李明轩,陈忆思.~(99m)Tc-标记尿激酶(血栓显像剂)的研制及动物实验[J].核技术,1984(6). |
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| 作者姓名： | 方瑞英 赵惠扬 刘文官 钱峰 陈可靖 冯友贤 杨国华 郑佳仅 范梅影 吴伯惠 李明轩 陈忆思 |
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| 作者单位： | 上海第一医学院附属中山医院
(方瑞英，赵惠扬，刘文官，钱峰，陈可靖，冯友贤，杨国华，郑佳仅，范梅影)，上海试剂研究所
(吴伯惠)，上海生物制药厂
(李明轩)，上海生物制药厂(陈忆思) |
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| 摘 要： | 尿激酶(Urokinase)为自人尿中提取的高纯度的乾冻酶制剂。尿激酶能直接激活体内纤溶酶元,转变为纤溶酶。纤溶酶具有强烈的水解纤维蛋白的作用,从而达到溶解血栓的效果。用~(99m)Tc标记尿激酶后,仍然保持一定的生物活力,将标记物注入到人体后,通过γ照相或闪烁扫描进行显像可以寻找血栓位置。 由于尿激酶不具有抗原性,故不会引起过敏反应,用~(99m)Tc标记尿激酶不仅用于肢体深静脉血栓的诊断,
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| 关 键 词： | ~(99m)Tc标记尿激酶 血栓 栓塞 |
The preparation of ~(99m)Tc-labelled urokinase as a thromboemboli imaging agent and its animals tests |
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| Fang Ruiying Zhao Huiyang Liu Wenguan Qian Feng Chen Kejing Feng Youxian Yang Guohua Zheng Jiajin Fan MeiyingWu Bohui Li Mingxuan Chen Yisi.The preparation of ~(99m)Tc-labelled urokinase as a thromboemboli imaging agent and its animals tests[J].Nuclear Techniques,1984(6). |
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| Authors: | Fang Ruiying Zhao Huiyang Liu Wenguan Qian Feng Chen Kejing Feng Youxian Yang Guohua Zheng Jiajin Fan MeiyingWu Bohui Li Mingxuan Chen Yisi |
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| Abstract: | This paper describes the preparation and animal tests of 99mTc-labelled urokinase thromboemboli imaging agent. This agent can be localized in thrombus after injection and visualized by Gamma camera or scintillation scanner. There is no allergic reaction from non antigen reaction.99mTc-urokinase can be used not only in diagnosis of deep vein thrombosis, but also in locating thrombus in transplant organs. |
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| Keywords: | technetium-99m labelled urbkinase thrombosis embolism |
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