Biodegradable poly(lactide-co-glycolide) coatings on magnesium alloys for orthopedic applications |
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Authors: | Nicole J Ostrowski Boeun Lee Abhijit Roy Madhumati Ramanathan Prashant N Kumta |
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Affiliation: | 1. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA 6. Swanson School of Engineering and School of Dental Medicine, University of Pittsburgh, 849 Benedum Hall, Pittsburgh, PA, 15261, USA 2. Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA 3. Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA, 15261, USA 4. Center for Craniofacial Regeneration, University of Pittsburgh, Pittsburgh, PA, 15261, USA 5. Center for Complex Engineered Multifunctional Materials (CCEMM), University of Pittsburgh, Pittsburgh, PA, 15261, USA
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Abstract: | Polymeric film coatings were applied by dip coating on two magnesium alloy systems, AZ31 and Mg4Y, in an attempt to slow the degradation of these alloys under in vitro conditions. Poly(lactic-co-glycolic acid) polymer in solution was explored at various concentrations, yielding coatings of varying thicknesses on the alloy substrates. Electrochemical corrosion studies indicate that the coatings initially provide some corrosion protection. Degradation studies showed reduced degradation over 3 days, but beyond this time point however, do not maintain a reduction in corrosion rate. Scanning electron microscopy indicates inhomogeneous coating durability, with gas pocket formation in the polymer coating, resulting in eventual detachment from the alloy surface. In vitro studies of cell viability utilizing mouse osteoblast cells showed improved biocompatibility of polymer coated substrates over the bare AZ31 and Mg4Y substrates. Results demonstrate that while challenges remain for long term degradation control, the developed polymeric coatings nevertheless provide short term corrosion protection and improved biocompatibility of magnesium alloys for possible use in orthopedic applications. |
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