10850例患者手术前肝炎病毒血清标志物分析

目的分析10850例患者手术前各型肝炎病毒的血清标志物,为加强医院生物安全防护和减少医院感染提供依据。方法采用化学发光微粒子免疫分析法检测HBsAg、Anti-HBs、HBeAg、Anti-HBe、Anti-HBc和Anti-HCV,酶联免疫法检测HAV-IgM和HEV-IgM。结果 10850例患者手术前HBsAg阳性率为6.52%,Anti-HBs阳性率为46.69%,HBeAg阳性率为1.85%,Anti-HBe阳性率为22.62%,Anti-HBc阳性率为45.83%,Anti-HCV阳性率为0.33%,HAV-IgM阳性率为0.17%,HEV-IgM阳性率为0.75%;男性HBV感染率明显高于女性(P<0.05);不同年龄段间HBV的感染率差异有统计学意义(P<0.01),0～20岁年龄段人群HBV的感染率明显低于其他年龄段(P<0.01),且该年龄段人群对HBV的保护力明显提高;不同年龄段人群间HAV感染率差异无统计学意义(P>0.05),而HCV和HEV感染率差异均有统计学意义(P<0.05);10850份标本共有17种乙肝标志物组合模式。结论 10850例患者手术前HBV感染率较高,HAV、HCV和HEV感染率不高,但也应引起重视。应进一步加强患者手术前肝炎病毒血清标志物的检测及医院的生物安全防护。

Analysis of Serum Markers of Hepatitis Virus in 10 850 Patients before Surgery

Objective To analyze the serum markers of hepatitis virus of various types in 10 850 patients and provide a basis for strengthening the bio-security and decreasing the infections in hospitals.Methods The HBsAg,anti-HBs,HBeAg,anti-HBe,antiHBc and anti-HCV of patients were determined by chemiluminescent microparticle immunoassay(CMIA),while the HAV-IgM and HEV-IgM by ELISA.Results The positive rates of HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc,anit-HCV,HAV-IgM and HEVIgM of 10 850 patients before surgery were 6.52%,46.69%,1.85%,22.62%,45.83%,0.33%,0.17% and 0.75% respectively.The infection rate of HBV was significantly higher in male patients than in female patients(P < 0.05),and significantly different in various age groups.The HBV infection rate of patients at ages of 0 ~ 20 years was significantly lower than those at other age groups,indicating increased protective level against HBV infection.The infection rate of HAV showed significant difference in the patients at various age groups(P > 0.05),while those of HCV and HEV showed significant difference(P < 0.05).A total of 17 modes of HBV markers were observed in the 10 850 patients.Conclusion The HBV infection rate is high in the patients before surgery.Though the infection rates of HAV,HCV and HEV are relative low,they shall be paid more attention.The determination of serum markers of hepatitis virus in the patients before surgery as well as the bio-security in hospital shall be strengthened.