| 5,6-二氨基-1-甲基-2,4-(1H,3H)嘧啶二酮的合成 |
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| 引用本文： | 马玉梅,贾云宏,蔡东.5,6-二氨基-1-甲基-2,4-(1H,3H)嘧啶二酮的合成[J].精细化工中间体,2010,40(2):51-53. |
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| 作者姓名： | 马玉梅 贾云宏 蔡东 |
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| 作者单位： | 辽宁医学院,药学院与研究生学院,辽宁,锦州,121000 |
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| 摘 要： | 甲基脲和氰乙酸乙酯在乙醇钠中缩合环化得到6-氨基尿嘧啶钠盐,钠盐酸化得6-氨基-1-甲基-2,4-(1H,3H)嘧啶二酮,再与亚硝酸盐亲电加成得到5-亚硝基-6-氨基-1-甲基-2,4-(1H,3H)嘧啶二酮,最后经连二亚硫酸钠还原得到5,6-二氨基-1-甲基-2,4-(1H,3H)嘧啶二酮,总收率为91.6%,其结构经1HNMR和IR表征。
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| 关 键 词： | 中间体 6-氨基-1-甲基-2 4-(1H 3H)-嘧啶二酮 5 6-二氨基-1-甲基-2 4-(1H 3H)嘧啶二酮 合成 |
Synthesis of 5,6-Diamino-1-methyl-2,4(1H,3H)-pyrimidine Dione |
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| MA Yu-mei,JIA YUN-hong,CAI Dong.Synthesis of 5,6-Diamino-1-methyl-2,4(1H,3H)-pyrimidine Dione[J].Fine Chemical Intermediates,2010,40(2):51-53. |
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| Authors: | MA Yu-mei JIA YUN-hong CAI Dong |
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| Affiliation: | (College of Pharmacy ＆ Graduate School, Liaoning Medical University, Jinzhou 121000, China) |
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| Abstract: | Methylurea and ethyl eyanoaeetate were reacted under catalysis of ethanol sodium to give sodium 6- amino uracil, followed by acidification to form 6--amino-1-methyl-2,4 -（1H, 3H） pyrimidine dione. The later was further converted to 5,6-diamino-1-methyl-2,4（1H, 3H）-pyrimidinedione in two steps. The process afforeded the title compound in 91.6% overall yield, which was confirmed with 1H NMR, IR and elemental analysis. |
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| Keywords: | intermediate 6-amino- 1-methyl-2 4 - （ 1H 3H） pyrimidine dione 5 6-diamino- 1-methyl-2 4 （ 1H 3H）-pyrimidinedione synthesis |
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