| 低聚壳聚糖复配体系对皮肤致病菌的体外抗菌活性研究 |
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| 引用本文： | 程晓静,黄群峰,徐云龙.低聚壳聚糖复配体系对皮肤致病菌的体外抗菌活性研究[J].材料导报,2016,30(Z2):313-316, 319. |
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| 作者姓名： | 程晓静 黄群峰 徐云龙 |
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| 作者单位： | 华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室, 上海 200237,华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室, 上海 200237,华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室, 上海 200237 |
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| 基金项目： | 程晓静:女,1991年生,硕士生,研究方向为生物医用材料 E-mail:wuyu5105@126.com 徐云龙:通讯作者,男,1962年生,博士,教授,研究方向为生物医药材料及肿瘤靶向制剂 E-mail:xuyunlong@ecust.edu.cn |
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| 摘 要： | 采用药敏纸片法和对倍稀释法分别考察了低聚壳聚糖与茶树油对化脓性链球菌、表皮葡萄球菌、金黄色葡萄球菌和大肠杆菌的抑菌性和最小抑菌浓度(MIC);采用定量法测定了低聚壳聚糖和茶树油复配体系的杀菌率,并与单组分杀菌率进行对比。结果表明:低聚壳聚糖和茶树油对4种实验菌均有抑菌性的MIC分别为0.5g/L和7.50mL/L;0.5g/L低聚壳聚糖与7.50mL/L茶树油复配后,对4种实验菌均有优异的杀菌率,复配体系明显优于单组分杀菌效果,其20min杀菌率均达到100%。
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| 关 键 词： | 低聚壳聚糖 茶树油 抗菌性 复配 |
Antibacterial Properties of Low Molecular-weight Chitosan Composite System Towards Skin Pathogenic Bacteria |
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| CHENG Xiaojing,HUANG Qunfeng and XU Yunlong.Antibacterial Properties of Low Molecular-weight Chitosan Composite System Towards Skin Pathogenic Bacteria[J].Materials Review,2016,30(Z2):313-316, 319. |
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| Authors: | CHENG Xiaojing HUANG Qunfeng and XU Yunlong |
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| Affiliation: | Key Laboratory of Ultra Fine Materials, Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237,Key Laboratory of Ultra Fine Materials, Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237 and Key Laboratory of Ultra Fine Materials, Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237 |
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| Abstract: | The antibacterial activity of low molecular-weight chitosan(LMC) and tea tree oil (TTO) against Streptococcus pyogenes (St.pyogenes), Staphylococcus epidermidis (St.epidermidis), Staphylococcus aureus (St.aureus) and Escherichia coli (E.coli) were determined by K-B method. The minimal inhibitory concentrations (MIC) of LMC and TTO were measured by tube dilution method. The sterilization rate of LMC and TTO composite liquid was tested by quantitative method, comparing with that of LMC or TTO. The results showed that LMC and TTO had inhibitory effect against all tested bacteria with minimum concentrations of 0.5 g/L and 7.50 mL/L, respectively. After compositing 0.5 g/L LMC and 7.50 mL/L TTO, the composite system exhibited an obviously higher bactericidal rate than before, the 20 min bactericidal rate was up to 100%. |
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| Keywords: | low molecular-weight chitosan tea tree oil antibacterial property composite |
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