Synthesis and characterization of mesoporous silica/poly(<Emphasis Type="Italic">N</Emphasis>-isopropylacrylamide) functional hybrid useful for drug delivery |
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Authors: | Andreza de Sousa Daniel Andrada Maria Ricardo Geraldo de Sousa Edésia Martins Barros de Sousa |
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Affiliation: | 1.Servi?o de Nanotecnologia—Centro de Desenvolvimento da Tecnologia Nuclear CDTN/CNEN,Belo Horizonte,Brazil;2.Departamento de Engenharia Química,E.E.UFMG,Belo Horizonte,Brazil |
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Abstract: | Recent studies indicate the use of mesoporous silica and polymeric sensitive hydrogels as suitable for drug delivery systems
due to their specific characteristics. Polymeric hydrogels, such as poly(N-isopropylacrylamide) P(N-iPAAm)], show volumetric expansion/contraction behaviour at 306 K, which that can be used to develop a thermosensitive drug
delivery system. In this study, we report a facile and direct synthesis route to obtain hybrid functional nanosystems based
on silica-P(N-iPAAm) by using a neutral surfactant and without any functionalization method and the assessment of its release rate of a
model drug. The materials were characterized by Fourier transform infrared spectroscopy, nitrogen adsorption, scanning electron
microscopy, transmission electron microscopy and thermal analysis. A release assay with atenolol monitored by UV–Vis spectroscopy
was performed for pure SBA-15 and a hybrid system at different temperatures in order to evaluate the influence of the thermosensitive
behaviour of the polymer on the release kinetics. The response of the hybrid system as a drug delivery device is influenced
by the volumetric contraction of P(N-iPAAm) up to the lower critical solution temperature (LCST) due to phase transition. Above the LCST, drug release depends
essentially on the temperature. |
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