| 胆甾醇辛酸酯-辛酰基-1-13C的合成 |
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| 引用本文： | 卢伟京,李帅,徐仲杰,卢浩.胆甾醇辛酸酯-辛酰基-1-13C的合成[J].同位素,2013,26(1):60-64. |
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| 作者姓名： | 卢伟京 李帅 徐仲杰 卢浩 |
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| 作者单位： | 上海化工研究院 |
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| 基金项目： | 国家高技术研究发展计划项目(2008AA02Z427) |
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| 摘 要： | 采用缩合与催化的组合方式，利用胆固醇（Ch-OH）与辛酸-1-13C反应，合成胆甾醇辛酸酯-辛酰基-1-13C（ChO-13C），产率84.1%，13C丰度99.0%，光学纯度99.0%，化学纯度99.5%。用HPLC-ELSD、LC-MS和1H NMR对产品进行表征，确定产品为胆甾醇辛酸酯结构。
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| 关 键 词： | 胆甾醇辛酸酯-辛酰基-1-13C 合成 13C标记 呼吸试剂 |
Synthesis of Cholesteryl Octanoate-octanoyl-1-13C |
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| LU Wei-jing,LI Shuai,XU Zhong-jie,LU Hao.Synthesis of Cholesteryl Octanoate-octanoyl-1-13C[J].Isotopes,2013,26(1):60-64. |
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| Authors: | LU Wei-jing LI Shuai XU Zhong-jie LU Hao |
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| Affiliation: | Shanghai Research Institute of Chemical Industry, Shanghai 200062, china |
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| Abstract: | Cholesteryl octanoate-octanoyl-1-13C was synthesized by a method of coupling-catalysis. The yield of 13C labeled Cholesteryl octanoate was 84.1% (based on Cholesterol), with 99.0% atom 13C 99.0% optical purity and 99.5% chemical purity. The product was characterized by HPLC-ELSD, LC-MS and 1H NMR. The structure and 13C isotopic enrichment of it was determined and measured by LC MS and 1H NMR. |
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| Keywords: | cholesteryl octanoate-octanoyl-1-13C synthesis 13C-labeled breath test substrates |
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