| 灯盏花乙素水解制备野黄芩素 |
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| 引用本文： | 廖霞俐,易东,张淼,杨霞,杨学敏,杨波.灯盏花乙素水解制备野黄芩素[J].昆明理工大学学报(理工版),2013(6):102-106. |
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| 作者姓名： | 廖霞俐 易东 张淼 杨霞 杨学敏 杨波 |
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| 作者单位： | 昆明理工大学生命科学与技术学院,云南昆明650500 |
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| 基金项目： | 国家自然科学基金（21062009）;云南省应用基础研究基金（2009ZC045M,2011FZ059）;云南省教育厅基金（2012Y533）. |
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| 摘 要： | 在乙醇-水溶液中对灯盏花乙素进行酸水解制备野黄芩素，用正交试验对水解工艺进行优化．得到最佳水解条件：温度80％，硫酸浓度20％（质量分数），乙醇浓度80％（体积分数），固液比1：2（质量-体积比，mg／mL），反应时间3．5h，该条件下的平均收率为90．7％．利用紫外光谱和核磁共振氢谱对其结构进行了表征．
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| 关 键 词： | 灯盏花乙素 野黄芩素 酸水解 正交试验 |
Preparation of Scutellarein by Hydrolysis of Scutellarin |
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| LIAO Xia-li,YI Dong,ZHANG Miao,YANG Xia,YANG Xue-min,YANG Bo.Preparation of Scutellarein by Hydrolysis of Scutellarin[J].Journal of Kunming University of Science and Technology(Natural Science Edition),2013(6):102-106. |
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| Authors: | LIAO Xia-li YI Dong ZHANG Miao YANG Xia YANG Xue-min YANG Bo |
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| Affiliation: | ( Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China) |
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| Abstract: | Scutellarein is prepared by acidic hydrolysis of scutellarin, and the reaction conditions are optimized through orthogonal experiments. The optimal conditions for scutellarein hydrolysis are as follows： the temperature being 80℃, the concentration of aqueous sulfuric acid being 20% （Mass fraction）, the concentration of aqueous ethanol being 20% （Volume fraction）, the ratio of solid material weight to solvent volume was 1：2 （Solid -liq- uid ratio,mg/mL） and the reaction time being 3.5 hours. The mean yield of scutellarein is 90.08% under the optimal reaction conditions. The title compound is characterized by UV and 1H- NMR spectroscopic analyses. |
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| Keywords: | Scutellarin Scutellarein acidic hydrolysis orthogonal experiment |
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