头孢曲松母液中回收2-巯基苯并噻唑新工艺

研究从头孢曲松生产母液中回收2 巯基苯并噻唑(以下简称M)，提出了蒸发结晶 加碱联合处理回收M的新工艺。采用失重法首次研究了M在不同溶剂体系中的溶解度，采用HPLC法测定母液蒸发浓缩结晶和加碱处理回收得到的M的质量分数。结果表明，M在丙酮中溶解度为15 g(常温)，在乙醇中溶解度为2.5 g(常温)，水的存在会使M在溶媒中的溶解度大幅降低，1.3 g［m(乙醇)∶m(水)=0.4∶0.6，75 ℃］；母液蒸发浓缩至85%时，M的收率可达98.6%，蒸发结晶和加碱处理回收得到的M的质量分数分别为98.2%和98.7%。该工艺不需要大量水的加入，降低了溶剂回收系统的能耗，酸碱用量少，无二次污染，不堵塞管道，已成功用于工业化生产。

New Process for Recovery of 2-Mercaptobenzothiazole from Ceftriaxone Mother Liquor

The process for recovery of 2-mercaptobenzothiazole（M） from ceftriaxone mother liquor was studied by experiment.Evaporation crystallization-alkaline treatment combined process was proposed.Weight loss method was used to determine the solubility of M in different solvent systems and the purity of M recovered from evaporation crystallization process and alkali treatment process was determined by HPLC.The solubility of M in acetone was 15 g/100 g（room temperature）,in ethanol was 2.5 g/100 g（room temperature）,but with the presence of water the solubility of M was significantly reduced,which is only 1.3 g/100 g in ethanol-water（mass ratio of 0.4∶0.6） at 75 ℃.When mother liquor was evaporated to 85%,the yield of M was 98.6% and the purity of M recovered from evaporation crystallization process and alkali treatment process were 98.2% and 98.7%,respectively.With advantages such as no requiring of water added which reduced the energy consumption of the solvent recovery system,less alkaline consumption,no secondary pollution and no pluging the pipe,the new process had already been successfully used in industrial production.